Abstract
ADVANCED STUDIES ON TRYPANOSOMA EVANSI

Safaa Mohamed Barghash*

ABSTRACT

Background: Cancer is an uncontrolled growth of abnormal cells found in animals and humans. This study aimed to discuss whether Trypanosoma evansi causes cancer or behaves like a cancerous cell and further assess the potential effects of sex on the measured parameters. Materials: Advanced tumour biomarkers and accompanied clinicopathological criteria were used to detect the progression of T. evansi in experimentally infected Albino Wistar rats. Results: Death appears highly correlated with the length of fulmination of parasitemia. The clinicopathological changes were associated with significant increases (P<0.05) in antitrypanosomal IgM, IgG and CEA, and highly significant differences (P<.0001) in the levels of malignant and tumour biomarkers IL-2, α-TNT, B2-M, AFP. In comparison, levels of CRP, CA-125, and CA-15.3 in females and CRP and serum PSA in males showed a non-significant increase (P>0.05). Similarly, CA-19.9 classes despite being elevated in infected males by the end of the experiment. Blood picture analysis showed leucopenia and anaemia rose significantly more in males than females. Biochemical analysis showed hypoglycemia, hypoproteinemia, hypolipidemia, and fluctuations in enzymes in both experimentally infected groups. Despite the examined tissues not being severely changeable by the infection in the short time of the experiment, T. evansi infection leads to further adverse pathogenesis for the host, causing cell and tissue destruction as generated by invasive cancer cells. Sex was a risk factor following the trypanosomal infection. Conclusions: The uncontrollable parasitaemia and the spread of T. evansi infection from the organ to others correspond with the style of malignancy, and T. evansi is possibly carcinogenic to rats.

Keywords: Cancer, Clinicopathological, Rats, Trypanosoma evansi, Tumour markers.


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