Abstract
A SYSTEMATIC REVIEW ON THE CURRENT STATUS OF BRIVARACETAM AS A MONOTHERAPY

Sumaiya Tabassum*, Mohammed Safi ur Rahman, Dr. Uzma Samreen, Dr. Mohammed Ashfaq Hussain,
Dr. BSV Raju and Dr. Anvesh Balabhadra

ABSTRACT

Brivaracetam (BRV) is the most recent Anti-Epileptic Drug to be licensed in Europe and the United States as an adjunctive treatment of focal onset seizures with or without secondary generalization. BRV was developed subsequently to develop an anticonvulsant compound with a higher affinity to the binding site synaptic vesicle protein 2A. BRV has been approved as a monotherapy and adjunctive drug in the management of partial-onset (focal) seizures and focal seizures both with and without secondary generalization, in 2018 USFDA has approved BRV as a monotherapy in adults and children above 4 years old, Within the European Union it is only approved as an adjunctive therapy. This review summarizes the essential preclinical and clinical data of BRV that is currently available.

Keywords: Brivaracetam, SV2AEpilepsy, monotherapy.


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