NANOSUSPENSION: A RISING DRUG DELIVERY SYSTEM
Rushikesh Sanjay Shewale*, Priti Tushar Newadkar, Prajwal Atmaram Wagh, Radhika Vilas Kharote, Unnati Sanjay Tribhuvan and Dr. Jayesh Vasudev Musale
ABSTRACT
Solubility proves to be an important limitation for the development and commercialization of new drug products. Due to this limitation, many pharmacologically active substances have failed to attain the market. Therefore, Nanosuspensions have emerged as a promising strategy for the efficient delivery of poorly water soluble substances due to their versatile characteristics and unique advantages. Various methods such as media milling and high pressure homogenization have been utilized for commercial production of nanosuspensions. Recently, the formulaion of nanosuspensions using emulsions and microemulsions as templates has been addressed in the literature. The unique features of nanosuspensions have enabled their use in several dosage forms, along with specialized delivery system such as mucoadhesive hydrogels. Rapid strides have been made in the delivery of nanosuspensions with the aid of parenteral, per-oral, ocular and pulmonary routes. Currently, efforts are being taken to extend their role in site-specific drug delivery.[1]
Keywords: Nanosuspension, Bioavailability, High pressure homogenization, Media milling, Solubility, Ostwald ripening.
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