OCULAR DRUG DELIVERY SYSTEM- A NOVEL THERAPEUTIC APPROACH
Shifa Haju*, Muskaan Ansari, Shweta Pal, Fatima Shaikh, Aaliya Siddiqui and Indira Parab
ABSTRACT
The purpose of this review is to give a recent update of the knowledge and challenges faced by today’s formulation scientists in the field of ocular drug delivery. The ocular preparations are available as sterile, buffered, isotonic solution. Topical eye drop is the convenient and patient complaint route of drug administration. Also, it involves development of conventional topical formulations such as suspensions, emulsions and ointments. The major problem encountered by the conventional ocular dosage form include frequent dosing, the rapid precorneal drug loss due to its nasolacrimal drainage, tear turnover and drug dilution resulting in poor bioavailability. These lead to development of controlled and sustained release novel ocular drug delivery dosage forms such as nanoparticle, liposomes, ocuserts, in-situ gel, implants, contact lens, microneedles and mucoadhesive formulation over conventional dosage forms in terms of enhancing bioavailability, possess high precorneal residence time, feasibility of topical application, decreasing dosage frequency and reduce toxicity. This review briefly describes advantages, limitation of conventional ocular dosage form, an anatomical protective barrier in ocular drug delivery, and recent novel approaches of ocular drug delivery for various treatment.
Keywords: Eye, ocular drug delivery, enhance bioavailability, novel approaches, sterile, precorneal residence time.
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