European Journal of Biomedical and Pharmaceutical Sciences

COMPARATIVE EVALUATION OF PROPOFOL WITH KETAMINE, BUTORPHANOL AND PENTAZOCINE IN SHORT SURGICAL PROCEDURE

Dr. Inder Dev Ashahiya*, Dr. Rajkumari Bansal, Dr. Neeraj Narang, Dr. Bhanu Choudhary, Dr. Sheetal Panwar

ABSTRACT

Background and Aims: The term „day-care surgery‟ and „ambulatory surgery‟ are used interchangeably for short surgical procedures which indicate that the patient is discharged on the day of surgery without overnight hospital stay. The aim of this study is to assess efficacy of Propofol in combination with either of Ketamine, Butorphanol or Pentazocine for short surgical procedures. Methods: Our study included 90 patients of both sex, aged between 18-50 years of ASA Grade I and II, scheduled for short surgical procedures. Group A patients were induced with Propofol (2.0-2.5 mg/kg) and Ketamine (0.5 mg/kg). Group B patients were induced with Propofol (2.0-2.5 mg/kg) and Pentazocine (0.5 mg/kg). Group C patients were induced with Propofol (2.0-2.5 mg/kg) and Butorphanol (0.03-0.05 mg/kg). Various parameters were recorded. Immediate recovery and Home readiness was assessed by Steward Scoring and Street fitness Criteria respectively. Results: Group A had best intraoperative cardiovascular stability and group C had best post operative cardiovascular stability. Immediate recovery and Home readiness was best observed in group B with maximum post operative analgesia requirement. Overall side effects were highest in group C. Conclusion: It could be concluded that combination of Propofol- Ketamine provides excellent haemodynamic stability, superior analgesia, less respiratory depression but associated with post operative complication viz; PONV.

Keywords: Propofol, Ketamine, Butorphanol, Pentazocine, Postoperative Analgesia.