Abstract
TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF HYDROPHOBIC DRUGS: A REVIEW

Vaishnavi S. Sake*, Rajendra K. Surawase, Shruti V. Raundal, Sudarshan B. Borse, Sonawane, Mayur M.

ABSTRACT

Dissolution of solute in solvent to give a homogeneous system to achieve desired concentration of drug in systematic circulation called solubility. Low aqueous solubility is excessively big problem for development of new synthetic drug formulation as well as generic development. Approximately 40% of all novel chemical substances are lipophilic in nature and neglect to have a broad therapeutic range due to poor aqueous solubility, resulting in limited bioavailability and poor water solubility. The main point of survey article is introduction of various techniques for solubility enhancement of low aqueous soluble drug and selection of solubility improving methods depends on drug property, site of absorption and required dosage form characteristics.

Keywords: Enhancement of Solubility, Solid Dispersion, Bioavailability, BCS Classification System.


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