Sangeeth C. K.*, Krishnananda Kamath K. and Shabaraya A. R.


Cubosomes, also known as bicontinuous cubic phase liquid crystals, are nanoparticles with a structure mostly composed of certain amphiphilic lipids in a specific proportion. Cubosomes are formed by hydrating a surfactant or polar lipid that generates a cubic phase and then dispersing a solid-like phase into smaller particles. They have honeycomb structures that are tightly packed twisted form three-dimensional bilayers and are thermodynamically stable. They are able to load more drugs because of their complex structure. Cubosomes can encapsulate hydrophobic, hydrophilic, and amphiphilic molecules. Ultrasonication techniques or high-pressure homogenization could be used to generate cubosomes using top-down and bottom-up procedures, respectively. Due to poor water solubility and limited corneal permeability, topical treatments currently on the market have low ocular bioavailability and insufficient medicine reaching the ciliary body. Several studies have shown that cubosomal ophthalmic drug delivery improves medicine bioavailability by enhancing trans corneal/transconjunctival penetration and improve medication bioavailability. Cubosomes also use full in in cancer therapy, oral drug delivery, Intravenous drug delivery, Topical drug delivery, sustained and targeted drug delivery applications.

Keywords: Cubosomes, Structure of Cubosomes, Methods of preparation, Ophthalmic delivery.

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