European Journal of Biomedical and Pharmaceutical Sciences

A STUDY OF CORRELATION OF THE PARAMETERS OF RENAL FUNCTION TESTS WITH THE PARAMETERS OF METABOLIC SYNDROME

Aakriti*, Jagruti Chandpa, Vatsal Vyas, Ravi Shingala, Gayatri Chudasama, Mihir Ankola and Abhishek Vadher

ABSTRACT

Background: Metabolic syndrome is a cluster of various metabolic abnormalities which lead to an increase in all cause mortality in the general population mostly due to cardiovascular and cerebrovascular events. It has been proposed that these metabolic abnormalities can also lead to renal dysfunction. This study was done to assess the renal functions parameters in Indian population patients with metabolic syndrome. Methods: This study was conducted at a university hospital with 200 participants. 100 patients had metabolic syndrome and 100 patients were taken as controls (Age, Sex, BMI matched). Serum Urea, serum Creat, 24 hour urine protein was measured in all the participants. The results were analysed using the chi square test. Results: We compared the findings in all the patients. A thorough physical examination, BMI etc was done in all the participants. There was a significant difference in all the renal parameters i.e. S.Urea, S.Creat, eGFR, 24 hour urine protein in the study population when compared with the control population. 68 patients in the study group had altered renal parameters and 15 participants in the control group had altered renal parameters. On comparing the individual parameters, there was a significant correlation between fasting blood glucose (p=0.03), systolic blood pressure (p=0.01) and diastolic blood pressure (p=0.036). Conclusion: There is significant derangement of renal parameters in obese individuals with metabolic syndrome when compared to obese without metabolic syndrome. There is an individual association of the parameters of metabolic syndrome with the renal function parameters.

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