European Journal of Biomedical and Pharmaceutical Sciences

ANTIOBESITY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF SPONDIAS PINNATA FRUITS IN RATS

Karunakar Hegde*, Vijetha Poojary K. and Munawar Muneer K. V.

ABSTRACT

The anti-obesity activity of Spondias pinnata fruits against Cafeteria diet induced and Fructose diet induced obesity in rats was performed. Two doses 200 mg/kg and 400 mg/kg b.w p.o of the extract were subjected for the evaluation of anti-obesity activity against the obesity induced by feeding cafeteria diet and fructose diet. Orlistat was served as standard drug in both the models. Evaluation of body weight, serum lipid profile and glucose level, liver weight and its triglyceride (TG) level was carried out in above experimental models. Body temperature and locomotor activity was also evaluated. Orlistat(10mg/kg) and Spondias pinnata hydroalcoholic extract (200mg/kg) and (400mg/kg) treated animals significantly decreased body weight, liver weight, serum lipid profile and glucose level, liver TG level in all experimental models compared to obese control animals. The present study concluded that Spondias pinnata fruits were found to be helpful in lowering body weight, total cholesterol, triglyceride, LDL, VLDL, and increasing HDL levels in both the obese models. Result of biochemical estimation indicates the Spondias pinnata hydroalcoholic extract (400mg/kg) showed significant results with Orlistat. The mechanism has pointed towards inhibiting cholesterol and triglyceride synthesis.

Keywords: Obesity, Orlistat, Serum lipid profile, Spondias pinnata.