European Journal of Biomedical and Pharmaceutical Sciences

ENHANCEMENT OF DISSOLUTION RATE OF POORLY SOLUBLE DRUG CARVEDILOL BY SOLID DISPERSION TECHNIQUE

S. K. Aadiba*, A. Masud Ahmed, S. Fahad, S. Abdul Salam, M. Dina Rasool and CH. Vidhyulatha

ABSTRACT

The main objective of present work enhancement of dissolution rate and oral bioavailability of poorly soluble drugs remains one of the most challenging aspects of drug development. In the present investigation studies were carried out on enhancement of dissolution rate of Carvedilol by Solid Dispersion technology (physical mixture, solvent evaporation, Kneading method) employing various water dispersible carriers. γ-CD’s, β-CD’s were evaluated as carriers for Solid Dispersions and for enhancing the dissolution rate of poorly soluble drug. All the dissolution parameters estimated i.e. R2and K1 values indicated rapid and higher dissolution of drug (Carvedilol) from Solid Dispersions than that of corresponding pure drug. The order of increase in dissolution rate with different Cyclodextrin’s is γ-CD’s <β-CD’s with Pure Carvedilol in powder form. Over all the carriers gave marked enhancement of solubility of Carvedilol. Among all β- CD’s in the ratio 1:1 (KM II) was found to be good carrier for Solid Dispersions for enhancing the dissolution rate of Carvedilol.

Keywords: Carvedilol , ?-CD’s, ?-CD’s, kneeding Method.