FORMULATION AND CHARATERIZATION OF RUTIN PERIO DONTAL FILMS FOR LOCAL DELIVERY OF ANTIMICROBIALS
K. S. Srilatha*, Dr. Suresh V. Kulkarani, Dr. P. Ashok Kumar and Dr. B. Gopalakrishna
ABSTRACT
A novel periodontal film for the treatment of periodontitis was developed by using herbal drug Rutin, It is also called rutoside and sophorin. It is a citrus flavonoid found in a wide variety of plants including citrus leaves and having antimicrobial activity and effective against infecting microorganisms in the periodontal pocket. Calibration curves for Rutin was developed in phosphate buffer PH 6.6, FT-IR studies was performed, which revealed that no interaction between the selected drug and polymers. Differential scanning calorimetry was performed to the identification of various physical properties and thermal transitions of drug and the polymeric materials. Periodontal films were prepared by solvent casting technique using Eutragit and HPMC as polymers Dibutyl phthalate as plasticizers and PEG as surface active agent. The formulated periodontal films were evaluated for their folding endurance, percent moisture loss, surface pH, viscosity, thickness, uniformity of weight, content uniformity, and in-vitro release. Scanning electron microscopy was done to study the surface characteristics of the patch on placebo and optimized formulation F3 before dissolution and after dissolution. SEM analysis revealed that the drug was uniformly distributed in patch and drug was released by diffusion. Data of In-vitro release from the formulated periodontal films were fit to different equations and kinetic models to explain release kinetics. Kinetic models used were zero first-order equations and Higuchi models. The release mechanism was understood by fitting the data to Korsemeyer-Peppas model.
Keywords: Rutin periodontal film, Periodontitis, Controlled release and Gingivitis.
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