Abstract
FORMULATION AND EVALUATION OF FAST DISINTEGRATING CLOPIDOGREL TABLET BY DIRECT COMPRESSION METHOD

Sudarshan B. Borse*, Dr. Avish D. Maru, Rajendra K. Surawase, Dr. Santosh S. Surana, Mayur M. Sonawane, Shruti V. Raundal

ABSTRACT

The primary goal of this research project is to develop Clopidogrel Fast Disintegrating tablets by direct compression method. Clopidogrel, a BCS Class-II antiplatelet medication, is used to prevent heart attacks and hypertension by reducing platelet activation and aggregation. Clopidogrel Fast Disintegrating Tablets were made utilizing the Direct Compression technique, clopidogrel, Sodium Starch glycolate, croscarmellose sodium, polyvinylpyrrolidone (PVP), Mannitol, Magnesium stearate, Talc, Lactose were used for preparation of tablet with varying concentrations of Sodium Starch glycolate and Croscarmellose sodium in different combinations as a Superdisintegrant. Sodium Starch glycolate and Croscarmellose sodium concentrations were chosen as independent variables (X and X, respectively),Formulation F3 can be Considered as an optimized, Nine formulations were created and tested in terms of hardness, Thickness, Friability, wetting time, disintegration time, and in-vitro drug release. Can be successfully formulated while also increasing bioavailability.

Keywords: Clopidogrel, Direct compression Method, Superdisintegrants, Bioavailability, Antiplatelet, etc.


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