European Journal of Biomedical and Pharmaceutical Sciences

EFFECTS OF VITAMIN A IN HYPERTENSIVE DISORDER OF PREGNANCY

*Dr. Dipendra Prasad Yadav and Shi Ji Fan

ABSTRACT

Objective: To evaluate effects of the serum level of vitamin A in hypertensive disorder of pregnancy, on maternal and newborn and their clinical outcomes. Material and Methods: A prospective cohort study. All total 958 pregnant women, admitted in obstetrics and gynecology department of first Affiliated Hospital of Dali University in Yunnan province from June 2017 to May 2018 included in study group who fulfilling the inclusion criteria. All the pregnant women selected randomly between the age 22 to 35 years and divided into four group. In the control group (normal pregnancy) 501 cases, 151 cases in GH Group, 126 cases in preeclampsia group, 180 cases of severe preeclampsia group. serum vitamin A detected by liquid chromatography-tandem mass spectrometry(LC-MS/MS). the data were statistically analyzed. the difference were Statistically significant at p<0.05. Result: There was no statistically significant difference in the results of all studies on maternal age, parity, BMI, and gestational weeks in the third trimester (p>0.05). There was no significant difference between the GH group and the control group (p >0.5). There is significant difference between preeclampsia group and severe preeclampsia group(p<0.05). There is significant difference in vitamin A deficiency between the control group, the GH group, when vitamin A was severely deficient, the proportions of severe preeclampsia, preeclampsia, gestational hypertension and control group were 60.0%, 56.0%, 36.4%, and 0.4%, respectively, and the difference was statistically significant (p<0.05). There was no significant difference in cesarean section rate and spontaneous birth rate between gestational hypertension group and preeclampsia group (p>0.05). when the third trimester serum vitamin A<0.2mg/L vs. ≥ 0.2mg/L, the risk of preeclampsia group and severe preeclampsia group increased by 1 and 2 times respectively, the difference was statistically significant (p<0.05). the risk of severe preeclampsia was increased by 3 times, and the difference was statistically significant (p<0.05). risk of preeclampsia no increase, the difference was not statistically significant (p>0.05). Conclusion: The content of vitamin A is related to the occurrence of hypertensive disorders of pregnancy. The deficiency of vitamin A increase the risk of severe preeclampsia risk increased. Detection of serum levels of vitamin A during pregnancy can help predict Gestational hypertension.

Keywords: vitamin A, gestational hypertension, preeclampsia.