European Journal of Biomedical and Pharmaceutical Sciences

STUDY ON DRUG EVALUATION AND UTILIZATION OF NON STEROIDAL ANTI INFLAMMATORY DRUGS: PROSPECTIVE OBSERVATIONAL

Dr. P. V. Madhava Reddy*, Dr. Y. Hrushikesh Reddy*, Dr. A. Santhi Sri, K. Syamala, M. Ramya, P. Guna Pravallika and T. Vijay Teja

ABSTRACT

Non-Steroidal Anti-Inflammatory Drugs are the class of drugs that provide analgesic, antipyretic(fever reducing) and in higher doses anti-inflammatory effects. The term “Nonsteroidal” distinguishes these drugs from steroids, which among broad range of other effects have a similar Eicosanoids depressing anti-inflammatory effect. As analgesics, Nonsteroidal anti-inflammatory drugs are unusual in that they non-narcotic. Nonsteroidal anti-inflammatory drugs the most highly prescribed drugs in the world, and also prevalently used in the age group of (0-10) years patients. The Paracetamol and Diclofenac were most frequently prescribed for the management of Pyrexia, Pain, Inflammation and Traumatic injury. Their Analgesic, Anti-inflammatory and Antipyretic actions may be beneficial, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. The monotherapy with single Nonsteroidal anti-inflammatory drug were preferred mode of therapy via parenteral and oral routes. Nonsteroidal anti-inflammatory drugs were mostly co-prescribed with proton pump inhibitors. Use of Nonsteroidal anti-inflammatory drugs are more than Cox-2 inhibitors. Ketorolac was the most frequently used drug 29.3% in general hospitals and Diclofenac used at the rate 50% in specialized hospitals. The purpose of Drug Utilization and Evaluation is to ensure that drugs are used appropriately, safely and effectively to improve patient health status. This project also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of Novel drugs to maintain the Anti-inflammatory functions of Nonsteroidal anti-inflammatory drugs along with effective gastrointestinal protection.

Keywords: Analgesic, Anti-inflammatory, Nonsteroidal anti-inflammatory drugs, GI damage.