PHARMACEUTICALLY USED PLASTICIZERS: A REVIEW
Sachin B. Somwanshi*, Ramdas T. Dolas, V. D. Wagh, K. B. Kotade
ABSTRACT
A plasticizer is a substance the addition of which to another material makes that material softer and more flexible.
Most often plasticizers are materials which, when added to a polymer, cause an increase in the flexibility and
workability, brought about by a decrease in the glass-transition temperature of the polymer. This article provides
an overview of the important types of plasticizers which exist, and gives details of properties of the plasticizers.
The choice of an appropriate plasticizer requires a wide background of information. This is because they are
incorporated into drug delivery systems containing an assortment of ingredients which may have different
reactions to the presence of plasticizers. The mechanism of action of plasticizers is described, in terms of
plasticization theory and the chemical modifications that occur during this process, which account for the excellent
performance of some plasticizer molecules and the apparently poor softening ability of others. The current
legislative and toxicological status of plasticizers is thoroughly reviewed to provide information about the
environmental effects of this widespread use of these products.
Keywords: Plasticizer, Polymer, Release, Flexibility.
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