Abstract
PREPARATION AND EVALUATION OF BEDAQUILINE LOADED MICROSPHERES BY TWO DIFFERENT TECHNIQUES

J. Adlin Jino Nesalin and Manu Kumar M. S.*

ABSTRACT

The present study is an attempt to prepare and evaluate Microspheres of Bedaquiline by using ethyl cellulose and Chitosan as polymers for treating Tuberculosis. The Bedaquiline loaded Microspheres were prepared by ionic gelation technique and solvent evaporation method. The drug and physical mixture were characterized by FTIR, their results indicates that there was no interaction between the drug and polymer. Changing the polymer concentration ratio will significantly affect the in-vitro drug release. The formulated Microspheres were evaluated for solubility, percentage yield, scanning electron microscopy, particle size, and in-vitro release. Among ten formulations FS5 of solvent evaporation method and F1of ionic gelation technique were selected as ideal formulation. The short-term stability studies on the optimized formulations indicate that there were slight physical or chemical changes in the formulations during the 3-month study period time. According to the data obtained from Bedaquiline loaded microspheres. Comparative study of two different methods shows that Ionic gelation method is better alternative to solvent evaporation method.

Keywords: Microspheres, Tuberculosis, Chitosan, Ethyl cellulose, Bedaquiline, Methods.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2022 Issue has been successfully launched on 1 June 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT