European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF BEDAQUILINE LOADED MICROSPHERES BY TWO DIFFERENT TECHNIQUES

J. Adlin Jino Nesalin and Manu Kumar M. S.*

ABSTRACT

The present study is an attempt to prepare and evaluate Microspheres of Bedaquiline by using ethyl cellulose and Chitosan as polymers for treating Tuberculosis. The Bedaquiline loaded Microspheres were prepared by ionic gelation technique and solvent evaporation method. The drug and physical mixture were characterized by FTIR, their results indicates that there was no interaction between the drug and polymer. Changing the polymer concentration ratio will significantly affect the in-vitro drug release. The formulated Microspheres were evaluated for solubility, percentage yield, scanning electron microscopy, particle size, and in-vitro release. Among ten formulations FS5 of solvent evaporation method and F1of ionic gelation technique were selected as ideal formulation. The short-term stability studies on the optimized formulations indicate that there were slight physical or chemical changes in the formulations during the 3-month study period time. According to the data obtained from Bedaquiline loaded microspheres. Comparative study of two different methods shows that Ionic gelation method is better alternative to solvent evaporation method.

Keywords: Microspheres, Tuberculosis, Chitosan, Ethyl cellulose, Bedaquiline, Methods.