European Journal of Biomedical and Pharmaceutical Sciences

AN OVERVIWE: DRUG DISCOVRERY AND CHEMISTRY OF HETEROCYCLIC COMPOUND

Pravin Sanjay Sake*, Dr. Manoj S. Charade and Varsha Vasant Kamble

ABSTRACT

The process of drug discovery can be described as the identification and validation of a target disease and target interact with that chemical compound in discovery and development. This interaction may be inhibit, foster or otherwise change the activity of the target. Development of drug involves fulfilled all requirements that have to be met before a new compound can be consider as ready for testing in the first time for human subjects. Testing of drug is done by preclinical and clinical trials.[1] The pharmaceutical industry on research-based has increasingly due use of modern medicinal chemistry methods, such as molecular modelling, the structure-activity relationships (SAR) can study by these powerful tool. These methodologies also used to study the pharmacodynamics data (e.g., selectivity, affinity, efficacy, potency) as well as pharmacokinetic properties (ADMET: absorption, distribution, metabolism, excretion and toxicity). The field has progressed due to advances in bio molecular spectroscopic methods such as X-ray crystallography and nuclear magnetic resonance (NMR), which have enabled striking progress in molecular and structural biology. These spectroscopic methods which have allowed to more than 100,000 the resolve three-dimensional molecular protein target structures that means providing crucial structural information about drug targets of macromolecule. Both academia and industry SBDD and LBDD approaches have been applied as valuable drug discovery tools. These approaches has been successfully employed in a number of investigations due to structural, chemical and biological data.[1,2] Heterocyclic chemistry is one of the branch of chemistry dealing with synthesis, properties, and applications of heterocyclic compound. Heterocyclic chemistry began in the 1800s, in 1818 something developing: in 1832 isolation of alloxan from uric acid by Brugnatelli, obtaining the furan by reaction with sulphuric acid in 1832s, dry distillation used for obtaining of Pyrrolin 1834.

Keywords: Drug Discovery, Heterocyclic Chemistry etc.