Surabhi Satheesan*, Krishnananda Kamath K. and Shabaraya A.R.


Cubosomes are square or spherical particles having visible cubic lattices on the inside. Cubosome discovery is a fascinating narrative that involves food science, differential geometry, biological membranes, and digestive processes. Cubosomes have a "honey combed" structure and are thermodynamically stable. Cubosomes are made up of amphiphilic lipids that are held together by a polymer. Cubosomes can be used to treat skin, hair, and other bodily tissues in a variety of ways, including parenteral, oral, mucosal, and transdermal. Cubosome formation may be tweaked to design pore size or include bioactive lipids, and polymers can be utilised to target the outer circle. They're also quite safe under physiological conditions. They have more drug trapping potential with their network topology. Cubosomes are nanostructured liquid crystalline particles that self-assemble and have a different internal cubic structure and content. Cubosomes are formed by hydrating a surfactant or polar lipid that generates a cubic phase and then dispersing a solid-like phase into smaller particles. They have solid-like rheology with unique features that are useful in practise. Cubosomes can encapsulate hydrophobic, hydrophilic, and amphiphilic molecules. Cubosomes can improve the solubility of drugs that aren't very soluble. Applications of cubosomes includes treatment of skin, hair, and other body tissue using cubosome-like vehicle activity of biological substances, regulated release of solubilized chemicals. Melanoma (cancer) therapy based on a size delivery system is the key to effectively targeting melanoma due to increased permeability and retention.

Keywords: Cubosomes, Nano carriers, Lipid, Anticancer therapy.

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