European Journal of Biomedical and Pharmaceutical Sciences

POLYMERIC MICROSPHERES: A REVIEW

Somani Neelam*, Bharkatiya Meenakshi

ABSTRACT

Over the conventional therapy, the novel drug delivery systems have much advantages. In the recent trends the microparticulate drug delivery are especially suitable for achieving the controlled or delayed release oral formulations. Oral formulations have risk of dose dumping, poor bioavailability and short gastric residence time. One such approach is using microspheres as delivery system; a well-designed controlled release system can overcome problems related to conventional therapy. Microspheres can enhance the therapeutical efficacy of particular drug. Microspheres are free flowing powder consisting of natural or synthetic polymers which are biodegradable in nature. Microspheres ideally having a particle size less than 500 μm. Microspheres received much attention not only for the prolong drug release but also for targeting release of certain drugs in severe diseases like cancer. Microspheres as delivery system offers numerous advantages, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. This review article highlights various types of microspheres, method of preparations, its advantages and evaluation parameters to check its efficiency.

Keywords: Conventional, Microspheres, Controlled Release, Targeted Release, Patient Compliance, Bioavailability, Dose Dumping, Microparticulate, Polymer, Biodegradable.