Abstract
FORMULATION AND EVALUATION OF PATCH FOR TRANSDERMAL DELIVERY OF ANTIHISTAMINIC DRUG LORATADINE

Devendra Pal* and Pradeep Chauhan

ABSTRACT

The present investigation was undertaken with an objective to improve the bioavailability of antihistaminic drug loratadine by formulation it as transdermal patch. Solvent casting method was used to formulate the patch employing carbopol and ethylcellulose as the patch forming polymers. Polyethylene glycol (PEG 400) was used as the plasticizer in the formlations. The drug content for Loratadine transdermal patches formulated with carbopol and ethyl cellulose ranged between 102.16±6.95 to 82.49±7.81%. The in vitro permeation study revealed that 64 to 91% of loratadine permeated from various formulations over 24 hours. The kinetic study and mechanism for diffusion of Loratadine transdermal patches obeys mixed order kinetics.

Keywords: Loratadine, Transdermal patch, Solvent evaporation, Flux, Ethyl cellulose.


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