European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND CHARACTERIZATION OF IPN MICROSPHERES CONTAINING MIGLITOL BY USING IN HOUSE SYNTHESISED ACRYLAMIDE GRAFTED HPMC K100 GUM

Ashok Kumar P.*, Manjunath K., Ayesha Kubbra and Akshith K.

ABSTRACT

Objective: The intention of the study is to formulate a miglitol-loaded microsphere of HPMC K-100 and polyvinyl alcohol by emulsion crosslinking method using glutaraldehyde as a crosslinker. Method: Emulsion crosslinking method was employed in the synthesis where firstly Preparation of Acrylamide grafted HPMC gum was done with optimization of full factorial design and later Miglitol was entrapped in IPN microspheres of PVA and Am-g-HPMC. Results and Discussion: The drug-loaded IPN microspheres released 60-92% at 12 hours of release studies and drug release follows a diffusion-controlled release pattern. Prolonged time drug release was observed without collapsing the particle matrix. Conclusion: IPN microspheres-based delivery system can be a superior approach for controlled delivery of highly water-soluble drugs like Miglitol.

Keywords: Miglitol, Acrylamide HPMC K-100, Polyvinyl alcohol, Interpenetrating polymer network.