Abstract
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF SIMVASTATIN

Vaishali Wagh* and R. K. Surwase

ABSTRACT

Simvastatin belongs to a class of medications called HMG-CoA Reductase Inhibitors. The goal is to develop and test immediate-release Simvastatin tablets using the wet granulation process. The super disintegrants that were utilised were sodium starch glycolate and sodium croscarmellose. Formulations were developed by Simvastatin with varying quantities of cross-carmel sodium and sodium starch glycolate, (1%,2% and 3% )respectively. The formulations were assessed using a variety of pre- and post-compression characteristics, and an in vitro release study investigation. FTIR studies evaluated the interaction between the drug and polymer. The findings of batch 11 to 16 pre-compression parameters were compared to the prescribed limits. It was discovered that the batch 11 to 16 powder blend has good flow and compressibility properties. In formulation I1-I6, disintegration time was observed to be 3-8 min and 100% of the drug was released within a 10-60m time interval. After looking at several criteria, it was decided that the way Simvastatin release tablets were made worked well, as 12 of them showed that almost the entire drug was released within 10 minutes.

Keywords: Simvastatin, Antilipidemic Agent, Wet Granulation Method, Sodium Starch glycolate, Croscarmellose Sodium, Immediate Release Tablet.


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