FORMULATION AND EVALUATION OF FERULA ASAFOETIDA OINTMENT IN THE TREATMENT OF ACNE VULGARIS
Shalumol Varghese*, Diya K. Babu, Jiya Johnson, Shafna, Shalu Joseph and S. Karthik
ABSTRACT
The aim of the study was to formulate and evaluate asafoetida ointment, with an objective to treat acne. The study was carried out against Staphylococcus epidermidis, using 1% Clindamycin gel as standard. Asafoetida was extracted using various solvents and the anti-acne property of the extract was determined against Staphylococcus epidermidis, using Clindamycin as standard. A control test was done using the solvent to avoid any chances of interference in the anti-acne activity. The prepared extract was then incorporated into a fatty ointment base which was prepared by Fusion method. Then the ointment was evaluated for its parameters like drug content, spreadability, extrudability, pH, loss on drying, leakage test, washability, and Anti-bacterial activity. The ethyl acetate-asafoetida extract showed comparable zone of inhibition against Staphylococcus epidermidis as that of Clindamycin. The physicochemical parameters were evaluated and it was found that the ointment showed satisfactory results in terms of spreadability, extrudability, pH and washability. Asafoetida extract was found to have potential antimicrobial activity against microorganism. The ethyl acetate extract of asafoetida demonstrated more activity against Staphylococcus epidermidis than the other extracts and thus it is effective in the treatment of acne. The extract of asafoetida in ethyl acetate was formulated into an ointment for increasing their effectiveness and for their ease of application. As asafoetida is a natural substance, it exhibits fewer side effects when compared to other synthetic ingredients incorporated in ointments.
Keywords: Asafoetida, Ethyl acetate extract, Ointment, Anti-acne activity, Clindamycin, Fusion.
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