EVALUATION OF ANTICONVULSANT ACTIVITY OF WHOLE PLANT OF INDIGOFERA MYSORENSIS
Azmathunnisa Begum*, Iffath Rizwana, Mohammed Muqthadir, Khadejah Sultana, Syeda Nikhat Mehwish and Syeda Sidrah Habeeb
ABSTRACT
Epilepsy is a chronic CNS disorder characterized by brief episodesof seizures and excessive EEG discharge. Indigofera mysorensis used as a herbal medicine and is well known for its traditional uses such as expectorants, diuretics, laxative etc. The qualitative phytochemical analysis of ethanolic extract of Indigofera mysorensis. It contains alkaloids, Carbohydrates, Glycosides, Flavonoids, Tanins Proteins, Amino Acids. The Ethanol extract of Indigofera mysorensis delayed the onset and reduced the duration of convulsion in MES and PTZ induced convulsion models and can be used as an adjuvant therapy against cognitive deficit in convulsions. The extract also shows significant decrease in lipid peroxidation level and increase in reduced glutathione level, indicates that EEIM possess good antioxidant activity. Also, EEIM significantly increased the level of inhibitory neurotransmitter GABA and also showed increase in DA, NA and 5-HT levels. Hence it can be concluded that the EEIM possesses good anticonvulsant activity. Further studies are needed to explore the mechanism as well as the active principle responsible for the anticonvulsant activity of Indigofera mysorensis.
Keywords: Anticonvulsant activity, Indigofera mysorensis, Whole plant, Epilepsy, Ethanolic extract.
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