Abstract
DETERMINATION AND ESTIMATION OF CONCENTRATION OF ROSUVASTATIN CALCIUM AND EZETIMIBE TABLET IP IN A BULK DRUG AND PHARMACEUTICAL FORMULATION BY UV- VISIBLE SPECTROPHOTOMETRIC USING SIMULTANEOUS EQUATION METHOD

Nandedkar M. A.*, Todkari A. D., Temgire A. L., Yenge N. B., Thombare R. R., Surve A. S., Waghmode P. S., Oswal R. J., Bhujbal N. S. and Pawar S. D.

ABSTRACT

This article focuses on the UV Spectrophotometric estimation of a drug combination i .e Rosuvastatin Calcium and Ezetimibe, which is used in the treatment of hypercholesterolemia and hyperlipidemia. Rosuvastatin Calcium is a HMG-CoA inhibitor while Ezetimibe is an intestinal cholesterol inhibitor.The drug obeyed the Beer’s law and showed good correlation. Acetonitrile was used as a solvent. A simple, economic and precise Spectrophotometric method was developed for simultaneous estimation of Rosuvastatin Calcium and Ezetimibe in a combined dosage form.

Keywords: Rosuvastatin Calcium, Ezetimibe, UV-spectroscopy, Method development, ?max.


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