European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTI DIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF ANDROGRAPHIS ELONGATE LEAVES

Aamir Khan Yusuf Khan*, Javariya Mubin Sayyada, Maliha Asif, Noor Ul Huda and Maryam Mehnaz

ABSTRACT

Andrographis elongate is having ethnomedicinal use for anti-diabetic activity. The ethanolic extract from whole plant of Andrographis elongata were subjected to preliminary phytochemical analysis which shown presence of flavonoids, alkaloids, Glycosides, tannins, proteins, steroids and phenol with absence of saponins and anthroquinones. The anti-diabetic activity of leaves of Andrographis elongata is evidenced by blood glucose level, estimation of lipid profile activity of Andrographis elongata and the evident reduction in SGOT, SGPT in liver and creatinine in serum also proves that the Andrographis elongata reduced the Pancreas, liver damage which is common in diabetes.Thus, it may be concluded that Andrographis elongata produced significant antidiabetic activity in streptozotocin induced diabetic rats. The efficacy of the Andrographis elongata was comparable to that of Glibenclamide.

Keywords: Anti-diabetic activity, Andrographis elongate leaves, Phytochemical Qualitative Analysis, wistar albino rats.