European Journal of Biomedical and Pharmaceutical Sciences

ANTI-ULCER ACTIVITY OF CYPERUS ROTUNDUS IN WISTAR RATS

Zainab Mahveen*, Nashwa Salman Habeeb, Mohammed Haseeb Qureshi, Mohammed Saba and Summayah Farooqi

ABSTRACT

Peptic ulcer disease (PUD) is characterized by inflamed lesions or excavations of the mucosa and underlying tissue of the upper gastrointestinal tract. Cyperus rotundus is belongs to Cyperaceae family. The main aim of the study is to evaluate the antiulcer activity of Cyperus rotundus. The preliminary phytochemical investigation showed the presence of alkaloids, flavonoids, terpenoids, tannins, Glycosides, and phytosteroids. The pharmacological and acute toxicity studies of ethanol extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed (3 days) up to 2000mg/kg of body weight. Cyperus rotundus showed a dose dependent curative ratio compared to ulcer control groups. The extracts exhibited an inhibition percentage of 65.67, 72.43 and 86.49 at doses of 100, 200 and 400mg/kg doses respectively. The ulcer protective action of extracts at 400mg/kg was equal to that of standard drug omeprazole, which exhibited an inhibition percentage of 92.16. Oral administration of ethanolic extract of Cyperus rotundus 1h before the induction of stress, reduced the water immersion stress induced ulcers. The methanol extract of ethanolic extract of Cyperus rotundus exhibited a dose dependent inhibition percentage of 53.30, 71.11 and 87.69 at doses of 100, 200 and 400mg/kg dose respectively. This may be due to proton pump inhibitory activity of the extract. The standard drug omeprazole showed an inhibition percentage of 92.68.

Keywords: Anti-ulcer activity, Cyperus rotundus, Wistar rats, Peptic ulcer, Ethanol extract.