Abstract
COMPARATIVE STUDY FOR THE EVALUATION OF MARKETED FORMULATIONS OF ONDANSETRON HYDROCHLORIDE INJECTIONS BY UV VISIBLE SPECTROPHOTOMETRIC METHOD

Gopika V. C.*, Sajna John and Shabna Abdul Rasheed

ABSTRACT

To compare assay results of marketed Ondansetron hydrochloride injections. The method is truly based on measuring UV absorbance maximum at 306nm using methanol as solvent. Five different brands of Ondansetron hydrochloride injections were purchased from the market for the analysis. A standard solution of drug was initially prepared in methanol to get a concentration of 3μg/mL. The different aliquots of solution of five different brands were prepared to get a concentration of 3μg/mL. The percentage assay of each brand was calculated and their regression analysis was also performed. As per Indian pharmacopoeia, Ondansetron injection formulations should contain not less than 95.0% and not more than 105.0% of stated amount of Ondansetron hydrochloride. So from the results of our study, all selected brands were found to be within the limit.

Keywords: UV visible spectrophotometry, Ondansetron hydrochloride, Methanol, Injection, assay comparison.


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