European Journal of Biomedical and Pharmaceutical Sciences

THE REWARD DEFICIENCY SYNDROME (RDS) PARADIGM – RDS IS THE PHENOTYPE: ADDICTION AND MENTAL DISORDER ARE ENDOTYPES: ELLE FOUNDATION RESEARCH INSTITUTE 100S SERIES, FAMILY GENERATIONAL GENOMIC CASE SERIES STUDY #103.

Elizabeth Dale Gilley*

ABSTRACT

Both quantitative and qualitative observation are used for statistical analysis of the Reward Deficiency Syndrome phenotype, neurogenetic predisposition, for addiction and mental disorder endotypes, in this level 4 evidence, case series. In continuation of the Elle Foundation, 100 research series, Case Series 103 builds upon Case Study 101, in which we introduced the longitudinal study of our proband[1-2]; and Case Series 102[3] in which we compared biological sisters’ underlying neurogenetic predisposition for Reward Deficiency Syndrome (RDS). Case study series 103 observes a four generational family for polymorphic gene variances which predispose risk for Reward Deficiency Syndrome (RDS)[4-5] and compares reported lifespan experience of Diagnostic Statistical Manual of Mental Disorder (DSM).[6] Data was collected using personal interview, self-report, personality testing, the RDSQ29[7] and Genetic Addiction Risk Severity (GARS).[8] Result findings support the hypothesis that the proband’s polymorphic variances are shared by other family members, adding to the international body of evidence that RDS is a family disease, which should be treated as a frontline modality[9], on a continuum of care[10-11], beginning with Primary Physicians.[12] GARS testing for SUD patients, family members and the next generation of children is advised.

Keywords: Reward Deficiency Syndrome, Genomic Addiction Medicine, Precision Behavioral Medicine, Neurogenetics, Dopamine Homeostasis, Genetic Addiction Risk Severity (GARS).