Swathi K.*, A. R. Shabbaraya and Shripathy D.


Pellets are small, free-flowing, spherical particles made by agglomerating fine powders or granules of medicinal ingredients and excipients using proper processing equipment in the pharmaceutical business. Pelletization has attracted a lot of attention in recent years due to its multiple benefits over other similar techniques, such as dose homogeneity and dosage form design flexibility. Pelletization methods are used in the pharmaceutical industry nowadays in a variety of ways. Among them are the following: Extrusion-spheronization and solution/suspension layering are the most used procedures in the pharmaceutical sector. Among these include balling, compression, cryopelletization, dry powder layering, hot melt extrusion, and other novel methods. This review includes a quick overview of all essential processes, with a focus on extrusion-spheronization and solution stacking.Extrusion–spheronization is a multistep process that includes dry mixing, wet granulation, extrusion, spheronization, drying, and screening, whereas solution or suspension layering is the deposition of successive layers of drug and binder solution/ suspension on started seeds, which can be either an inert material or granules of the same drug. Because each technique has its own set of benefits and drawbacks, a full understanding of the process variables is essential before selecting a pelletization method.

Keywords: Pellets, Pelletisation technique, Micromeritic properties.

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