Abstract
ORGAN ON A CHIP: A NEW TOOL FOR DRUG DISCOVERY

Sristi Dutta and Souvik Sengupta*

ABSTRACT

Microfluidics is a science and technology that precisely manipulates and processes microscale fluids. It is commonly used to precisely control microfluidic (10−9 to 10−18 L) fluids using channels that range in size from tens to hundreds of microns and is known as a “lab-on-a-chip”. The microchannel is small, but has a large surface area and high mass transfer, favoring its use in microfluidic technology applications including low regent usage, controllable volumes, fast mixing speeds, rapid responses, and precision control of physical and chemical properties. Microfluidics integrate sample preparation, reactions, separation, detection, and basic operating units such as cell culture, sorting and cell lysis . For these reasons, interest in OOAC (Organ-On-A-Chip) has intensified. OOAC combines a range of chemical, biological and material science disciplines and was selected as one of the “Top Ten Emerging Technologies” in the World Economic Forum.

Keywords: Organ On A Chip, Lung On A Chip, Brain On A Chip, Heart On A Chip, Kidney On A Chip, Prostate On A Chip, Pancreas On A Chip, microfluidics.


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