European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON NOVEL APPROACHES TO DEVELOP CO-CRYSTALS FOR ELEGANT PRODUCT

Paul George*, Viresh K. Chandur and A. R. Shabaraya

ABSTRACT

The major constraints during the development of a new product are poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient. Several approaches have been used to improve the solubility of poorly aqueous soluble drugs, but their success is dependent on the physical and chemical nature of the molecules being developed. Cocrystallization of drug substances allows for the development of new drug products with improved physicochemical properties such as melting point, tabletability, solubility, stability, bioavailability, and permeability while maintaining the active pharmaceutical ingredient's pharmacological properties. Cocrystals are multicomponent systems in which two components, an active medicinal ingredient and a conformer are present in a stoichiometric ratio in the crystal lattice and are linked together by non-covalent interactions. This review article presents a systematic overview of pharmaceutical cocrystals. The theoretical parameters influencing coformer selection and cocrystal screening have been outlined, with several cocrystal creation and evaluation methodologies have been explained.

Keywords: Co-crystals, Coformers, Hansen Solubility Parameter, cocrystallization.