Abstract
A REVIEW ON NOVEL APPROACHES TO DEVELOP CO-CRYSTALS FOR ELEGANT PRODUCT

Paul George*, Viresh K. Chandur and A. R. Shabaraya

ABSTRACT

The major constraints during the development of a new product are poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient. Several approaches have been used to improve the solubility of poorly aqueous soluble drugs, but their success is dependent on the physical and chemical nature of the molecules being developed. Cocrystallization of drug substances allows for the development of new drug products with improved physicochemical properties such as melting point, tabletability, solubility, stability, bioavailability, and permeability while maintaining the active pharmaceutical ingredient's pharmacological properties. Cocrystals are multicomponent systems in which two components, an active medicinal ingredient and a conformer are present in a stoichiometric ratio in the crystal lattice and are linked together by non-covalent interactions. This review article presents a systematic overview of pharmaceutical cocrystals. The theoretical parameters influencing coformer selection and cocrystal screening have been outlined, with several cocrystal creation and evaluation methodologies have been explained.

Keywords: Co-crystals, Coformers, Hansen Solubility Parameter, cocrystallization.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: AUGUST ISSUE PUBLISHED

    AUGUST 2022 Issue has been successfully launched on 1 August 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT