European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF HEPATOPROTECTIVE AND ANTI OXIDANT POTENTIALS OF SEBESTIANA CHAMELEA LEAVES EXTRACT IN ALBINO RATS

Asif Rasheed*, Syed Mohammed Ali Raza, Mohammed Abdul Rehaan, Shahab Pasha and Umaima Batool Osmani

ABSTRACT

The liver is one of the vital organs of the body and plays a key role in the metabolism and detoxification process. Sebestiana chamelea is belongs to the Euphorbiaceae family. The main aim and objectives are evaluation of the phytochemical screening of various extracts of leaves of Sebestiana chamelea. Evaluation of the hepatoprotective activity of various extracts of leaves of Sebestiana chamelea in Carbon tetrachloride induced hepatotoxicity in rats. The different extracts of the leaves of Sebestiana chamelea possessed promising hepatoprotective activity against CCl4 induced hepatic damage. The hepatoprotective activity of Sebestiana chamelea is found out to be more in ethanolic extract. The activity could be due to the improvement in the antioxidant enzyme level and a decrease in free radical levels. The presence of phytochemicals such as flavonoids has been shown to be responsible for hepatoprotective activity. Further studies can be carried out in the future to elucidate the mechanism of action of the ethanolic extract of leaves of Sebestiana chamelea, which may then be followed and clinical studies to establish its efficacy in humans.

Keywords: Hepatoprotective activity, Anti-oxidant activity, Sebestiana chamelea leaves, Albino rats.