Abstract
FORMULATION AND EVALUATION OF DELAYED RELEASE PANTAPRAZOLE SPHERES BY USING FLUIDISED BED PROCESSOR

Shivaraj Bhaskar Pagare*, Dr. Avish D. Maru and Rajendra K. Surawase

ABSTRACT

The present study was an attempt to formulate and of Delayed Release Pantaprazole Spheres by Using Fluidised Bed Processor”. Different tablets were prepared and formulation in different batch, the suspension layering approach was utilised to produce pellets. Friability tests, assays, and in-vitro release studies were conducted for 1 hour in acidic media containing 0.1N HCL, followed by 1 hour in a 6.8 pH Phosphate buffer to evaluate the finished products. From the evaluation, it was determined that the percentages of friability and assay for all formulations from F1 to F9 fell within the acceptable range. Formulation F9 exhibited superior resistance to 0.1 N HCL and excellent solubility in phosphate buffer with a pH of 6.8 as determined by in vitro dissolution testing. Based on the aforementioned results and discussion, it is possible to conclude that formulation F9 of enteric coated pellets of Pantaprazole is stable in acidic medium and exhibits superior drug release in basic medium. Therefore, this formulation of enteric-coated pellets was perfect and optimised. The stability study was conducted for formulation F9 at 1 month for the invitro dissolution investigation, and it was observed that no changes occurred, indicating that the improved formulation F9 was stable.

Keywords: peptic ulcer, pantaprazole, enteric coated tablet, density.


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