Abstract
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRICMETHOD FOR THE ESTIMATION AND COMPARISON OF ONDANSETRON HYDROCHLORIDE IN BULK AND MARKETED TABLET DOSAGE FORMS

Sajna John*, Gopika V.C., Nihala P.M., Murshidha Mohammed, Jilgeo George and Hafiza Hamsa

ABSTRACT

A simple, accurate, precise, reproducible, highly sensitive economic spectrophotometric method has been developed for the estimation of Ondansetron hydrochloride in tablet dosage forms. UV spectrophotometric method is based on measurement absorption of maximum wavelength 306 nm in methanol. The developed method was validated with respect to linearity, accuracy (recovery), precision, LOD and LOQ. Beer’s law was obeyed in the concentration range of 1- 5 μg/mL with correlation coefficient value. Results of the analysis were validated statistically and by recovery study. Also compared the assay results of different available marketed tablet formulations of Ondansetron hydrochloride. All the brands were found to be within the limit as per Indian pharmacopoeia.

Keywords: UV visible spectrophotometry, Ondansetron hydrochloride, Tablet, Methanol, Validation.


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