EFFICACY AND SAFETY OF TRIPLE COMBINATION OF PANTOPRAZOLE, AMOXICILLIN, AND CLARITHROMYCIN IN PATIENTS WITH HELICOBACTER PYLORI INFECTION
Dr. Ajay Kumar, Dr. Dinesh Kansal*, Dr. Swatantra Gupta and Dr. Atal Sood
ABSTRACT
Objective: To assess the effectiveness of pantoprazole 40mg twice daily per oral, cap. amoxicillin 1000mg twice daily per oral, tab. clarithromycin 500mg twice daily per oral in the eradication of Helicobacter pylori. Methods: This prospective, interventional study was conducted in the Department of Pharmacology and Department of Gastroenterology and Hepatology at Dr. R.P.G.M.C. Kangra at Tanda between April 2020 and March 2021. The study was conducted after due permissions from the Institutional Ethics Committee and registration with Clinical Trial Registry- India (CTRI). The study population was the consenting adult patients (18-75 years) of dyspepsia (ulcer or non-ulcer) who were found to be H. pylori positive on gastric biopsy belonging to different socio-economic strata. The patients were selected from those coming to gastroenterology OPD. Results: Eradication rate of H. pylori was 84% at day-14 weeks after treatment was given. Adverse events were recorded in one patient only. Conclusion: This study demonstrates that a 14-day pantoprazole, clarithromycin, and amoxicillin is an effective and well tolerated therapeutic approach for H. pylori eradication.
Keywords: Helicobacter pylori, Duodenal ulcer, Triple regimen.
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