European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF NABUMETONE

Kakli Rai*, Vivek Kumar Patel, Rishabh Chaurasiya, Sushma Singh and Riya Singh

ABSTRACT

In the sector of medical practices, there is a vital impact of Transdermal Drug Delivery System. A Précised quantity of drug is delivered into the blood stream through the skin and it is delivered by the medicated patches. The Transdermal Drug Delivery having a merit over the other conventional system of drug delivery is that the drug is released in sustained form from the patches into the patients, and usually the drug the drug is released in control manner either from body heat melting thin layers of drug embedded in the adhesive or the drug is released from a reservoir covered by a porous membrane. Then main objective of the recent study is to prepare a transdermal patch of non-steroidal anti-inflammatory drug, Nabumetone using mercury substrate method and the physiochemical parameters were evaluated, the parameters such as weight variation, thickness, moisture uptake, moisture content, drug content, and folding endurance. There are total six transdermal patches were formulated by changing the concentration of ethyl cellulose.

Keywords: Transdermal patches, NSAIDs, Ethyl cellulose, Nabumetone, Skin, Inflammation, Permeation.