European Journal of Biomedical and Pharmaceutical Sciences

BEHAVIORAL AND NEUROBIOLOGICAL CONSEQUENCES OF HIGH-FAT DIET ON ALCOHOL AND NICOTINE DRINKING IN MALE WISTAR RAT

Ashvani Tripathi*, Abhishek Tripathi, Alok Mukerjee, Sunil Kumar Singh and Archita Srivastava

ABSTRACT

Consumption of ethanol and nicotine are highly co-consumptive condition for addictive drugs and rate of occurrence between alcohol and nicotine addiction is so high. Alcohol and nicotine shows the synergistic effect to each other with respect to neuronal changes in region of the brain. Consumption of addictive substances influenced on various neurotransmitters like dopamine, serotonin, GABA and acetylcholine. High fat diet (HFD), fat and calorie enriched food; consumption of HFD may consequences in reducing of alcohol and nicotine. High fat diet shows pharmacological results in alcohol use disorder (AUD), Anxiolytic and addictions like symptoms but how it works remains unclear. We first examined the alcohol and nicotine co- consumption in male Wistar rats by 3-bottle choice procedure; we found that rats are more interested in intake of alcohol rather than nicotine. We determined that intermittent and chronic HFD consumption help in reducing the alcohol consumption and nicotine consumption in male Wistar rat with the help of behavioral testing and neurobiological testing. In behavioral testing by light and dark box, high-fat diets also produce anxiolytic effect that spent more time in light side by chronic group and intermittent group of rat and spent more time in open area for same group. In our testing there is significantly correlation of HFD was found on alcohol and nicotine consumption.

Keywords: High fat diet, Alcohol, Nicotine, Alcohol use disorder, Drug dependence.