European Journal of Biomedical and Pharmaceutical Sciences

A PROSPECTIVE CROSS SECTIONAL OBSERVATIONAL STUDY ON PREVALENCE OF CLINICAL MANIFESTATIONS AND HORMONAL ABNORMALITIES ASSOCIATED WITH POLYCYSTIC OVARIAN DISEASE

Manvitha Y. Sravani*, M. Sudhakar, Malathi, B. Bhavani Janvivarma, Anusha, Ramya Uppala and Azmira Aktar

ABSTRACT

Background: Polycystic ovarian disorder (PCOD) is the most common hormonal disorder seen in females of reproductive worldwide. From the very limited data, PCOD prevalence in India ranges from 3.7% to 22.5%. Polycystic Ovarian disease requires "control" rather than "cure", the treatment decisions depend on symptoms, age, whether or not the women wants to become pregnant. Aim: To study the prevalence of clinical manifestations and hormonal abnormalities associated with PCOD. Methodology: This prospective observational study was carried out in gynaecology department of Mallareddy hospital, where subjects were enrolled based on inclusion and exclusion criteria. All 100 patients demographics were documented. The prevalence of clinical manifestations and hormonal abnormalities in all subjects were assessed. Results: Irregular menstruation was seen as the most common clinical manifestation and seen in maximum 66% of subjects, Hirsutism was seen in 35% of the cases followed by acne in 28% of cases, androgenic alopecia in 22% of cases and acanthosis nigricans in minority 7% of cases. When the subjects were assessed for hormonal abnormalities, 52% of the subjects showed decreased FSH, 48% of the subjects had increased LH, 9% had decreased and 33 % had increased PRL, 38% showed increased Testosterone, 21% had decreased and 7% had increased T3, T4 levels. Conclusion: Irregular menstruation was seen as the most common clinical manifestation followed by dermatologic manifestations – Hirsutism, Acne, Acanthosis nigricans and androgenic alopecia. Clinical manifestations diagnosis can lead to early treatment in these patients and helps them in relieving their symptoms and improve quality of life.

Keywords: Polycystic ovarian disease, Clinical manifestations, Hormonal abnormalities.