European Journal of Biomedical and Pharmaceutical Sciences

A CROSS-SECTIONAL STUDY ON THE EFFECT OF ANTI- HYPERTENSIVE DRUGS ON THE ARTERIAL STIFFNESS AMONG HYPERTENSIVE PATIENTS

M. Sudhakar*, Karuna Sree P., Vinayak Raj, Khatija Fatima, Uday Kiran, Marri Akshay, PDSS Prakash, M. Ramaiah

ABSTRACT

This study was conducted to assess the effect of various anti-hypertensive drugs on the arterial stiffness in hypertensive patients and to compare the effect of various anti-hypertensive drugs. Secondary objective was to assess the correlation between smoking, alcoholism, waist hip ratio, duration of hypertension and MAP with C-F PWV. Methodology-the study was a prospective cross-sectional multi-arm parallel-group observational study was conducted over a period of 6 months. Subjects were divided into 2 groups; Group one included hypertensive patients on regular treatment and group 2 had age-matched healthy controls with normal blood pressure. Results-The PWV, ASI, and pulse pressure vascular parameter were statistically higher in hypertensive patients than in controls. Different treatment groups were categorized based on the various anti- hypertensive therapies which were given to the study population and a comparison was done and there was no statistical significance between these groups concluding that arterial stiffness was equally high in both these sub-groups. The correlations were done between parameters like age group, smoking, alcoholism, duration of hypertension, waist-hip ratio and mean arterial pressure (MAP) with C-F PWV, and all the correlations were found to be statistically significant. Conclusion- Regardless of treatment status, non-diabetic chronic hypertensives subjects have higher PWV, ASI, and pulse pressure than controls.

Keywords: Hypertension, Arterial stiffness, Cardiovascular diseases, Anti-hypertensive.