European Journal of Biomedical and Pharmaceutical Sciences

CUBOSOMES: A POTENTIAL NANOCARRIER FOR DRUG DELIVERY

Pranav D.*, Viresh K. C. and Shabaraya A. R.

ABSTRACT

Cubosomes, also known as bicontinuous cubic phase liquid crystals, are nanoparticles with a specific ratio of amphiphilic lipids as their major constituents. Cubosomes are typically created by hydrating a surfactant or polar lipid that produces a cubic phase and then dispersing it into smaller particles. They exhibit unusual features of practical interest and solid-like rheology. They have carvenous (honeycomb) structures that are tightly packed and twisted into three-dimensional bilayers, and they are thermodynamically stable. They are extensively employed in a variety of drug delivery applications, including transdermal, oral, and chemotherapeutic drug administration. The pertinent literature on cubosomes, with a focus on theories of self-assembling, cubosome composition, preparation techniques, and drug delivery applications, will be critically addressed in this study.

Keywords: Cubosomes, Nanoparticles, Bicontinous, Honeycomb, Amphiphilic.