European Journal of Biomedical and Pharmaceutical Sciences

A POLYMERIC NANOPARTICLES WITH PROMISING ACTIVITY IN NANOSPONGE

Sangavi S., Dhanalakshmi S., Senthil Kumar M.* and Vigneshwaran L. V.

ABSTRACT

The most recent advancement in nanotechnology demonstrates that the current increased concentration has turned out to be the supramolecular gathering of simple constituents for therapeutic and diagnostic purposes. This review goes into great detail about the materials used to make nanosponges, as well as the various methods of preparation, characterization, and applications. Medical researchers are working on a solution to the problem of targeted drug delivery to specific sites. Nanosponge, a newly developed colloidal system, has the potential to solve these issues. They are a new type of highly cross-linked polymer found in colloidal structures that contain solid nanoparticles with nanoscale cavities and colloidal sizes. They improve drug release, increase stability, and reduce side effects. The outermost surface is typically porous, allowing for sustained drug release while also preventing drug and protein degradation. Nanosponges are microscopic sponges about the size of a virus that can be mixed with a variety of drugs. These tiny sponges can be dispersed throughout the body until they reach a specific target site, where they will stick to the surface and begin to release the drug in a controlled and predictable manner. Nanosponge particles can be made huge or tiny by changing the number of cross-linkers and polymers. These particles can transport both lipophilic and hydrophilic molecules and improve the solubility of molecules that are poorly water soluble.

Keywords: Nanosponge, Targeted drug delivery system, ? –cyclodextrins, cross linker.