European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS CHARACTERISATION AND ANTIMICROBIAL SCREENING OF HYDRAZONES OF COUMARIN HYDRAZIDES AND ISATIN.

Ganesh N. Alawandi*, Kiran K. Pujar and Manohar V. Kulkarni

ABSTRACT

Substituted 2-oxo-2H-chromen-4-ylmethyl Sulphanyl/Sulphonyl)-acetic acid hydrazides or coumarin carbahydrazides treated with isatin in ethanol reflux in presence of catalytic amount of acetic acid to yield desired corresponding hydrazones, thus newly synthesised compounds were established by IR, 1HNMR and mass spectral studies. All the title compounds were subjected to in vitro antibacterial testing against two pathogenic strains and antifungal testing against two fungi. Among the tested compounds 4c ,4d and 4f displayed significant antibacterial and antifungal activities and rest of them are the moderately active.

Keywords: Coumarin Sulphanyl/Sulphonyl)-acetic acidhydrazides or coumarin carbahydrazides, isatin, amido-iminol tautomerism, antibacterial and antifungal.