European Journal of Biomedical and Pharmaceutical Sciences

BETULA UTILIS D. DON: STUDY OF ANTICONVULSANT AND ANXIOLYTIC AGENT

Chakresh Patley*, Santosh Bhadhkariya, Kaminee Sahu, Seema Kohli and Rakesh Sagar

ABSTRACT

There is chemical examination and pharmacological activity of Betula utilisbark‖was studied. The bark of Betula utilis bark was collected from suburban hills of Uttrakhand and subjected to extraction in hydroalcoholic solvent. Extraction of bark of Betula utilis with hydroalcoholic solution yielded a dark brown, semi-solid residue (HABE) (9.0 %). The hydroalcoholic extract of Betula utilis was subjected to phytochemical investigation for further study of pharmacological activity. Acute oral toxicity study was perform according to OECD 425 Guidelines and revels that at dose of 2000 mg/kg, 63% of the animals died. So that 1/20th and 1/10th (i.e. 100mg/kg and 200 mg/kg orally) was selected for convulsant and anxiolytic activity. The extract showed a decrease in the duration of the extensor phase and an increase in percentage protection at doses of 100 and 200 mg/kg. Phenytoin completely inhibited the duration of the tonic extensor phase and protected 100% of animals.

Keywords: Betula utilis, Anxiolytic activity.