Abstract
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SUBSTITUTED PHENYL OXAZOLE -2,4-DIAMINE DERIVATIVES

Ashitha P.V.*, Nivea Cleo and Dr. Minu B. Pattasseril

ABSTRACT

The present study deals in the reaction of aniline with chloroacetyl chloride to produce an intermediate, which undergoes condensation with urea under reflux in the presence of ethanol to produce oxazole derivatives. The synthesized compounds were characterized by IR spectral data. The Compounds were screened for antimicrobial activity against strains of gram positive and negative bacteria. The synthesized compounds displayed interesting antimicrobial activity. Compounds 3b was the most potent in this study and displayed higher activity compared to the reference drugs. All the other compounds showed good to moderate antibacterial activity.

Keywords: Oxazole, Staphylococcus aureus, chloroacetylchloride, antimicrobial.


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