European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS OF ADVANCE THIAZOLE DERIVATIVES AND ESTIMATION OF THEIR ANTIMICROBIAL PROSPECTIVE

Somesh M. Bawane*, Pranali R. Gajbhiye, Nitin B. Kohale, Abhijit R. Raut, Ashwini D. Uke, Naresh D.
Masankar, Dipali S. Doifode and Nikita P. Aware

ABSTRACT

Thiazole, or 1,3-thiazole, is a heterocyclic compound that contains both sulfur and nitrogen; the term thiazole also refers to a large family of derivatives. Thiazole itself is a pale-yellow liquid with a pyridine-like odor and the molecular formula C3H3NS. The thiazole ring is notable as a component of the vitamin thiamine (B1). In the present study, an attempt has been made to synthesize and characterize some thiazole derivatives and to evaluate them for their antimicrobial activity. Compound Ia, Ib, IIa IIc and IIIb are effective against Gram-positive bacteria and compound Ib, IIa, IIIa, IIIb and IIIc are effective against Gram-negative bacteria. Only compound IIc and IIIc are effective against A. niger as compared with standard. Further, there is a large scope for development of other derivatives and their pharmacological screening. Since, the synthetic scheme is simple and now well established it would be easy to synthesize other derivatives by incorporating various substitutions and screening them for other pharmacological activities like anticancer, anticonvulsant and antiviral.

Keywords: Synthesis, Thiazole, Estimation, Gram-positive bacteria, Gram-negative bacteria.