Abstract
VALIDATED UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF BENIDIPINE HYDROCHLORIDE AND TELMISARTAN IN BULK AND PHARMACEUTICAL DOSAGE FORM

M. M. Eswarudu*, P. Srinivasa Babu, N. Sudhakar Reddy, G. Ouchitya, B. Vinay Kumar, S. Bhupathi Naidu, A. Prasanthi

ABSTRACT

A simple, economical, accurate, precise and less time-consuming UV Spectrophotometric method has been developed and validated for simultaneous estimation of Benidipine Hydrochloride and Telmisartan in bulk and pharmaceutical dosage form. In this method Benidipine HCl and Telmisartan are exhibits maximum absorbance (λ max) at 237 nm and 296 nm with methanol as the solvent. The method was validated as per the International Conference on Harmonization (ICHQ2R1) guidelines. Drugs followed the linearity in the concentration range of 1-5 μg/mL and 10-50 μg/mL with correlation coefficient (r2) of 0.9992 for Benidipine HCl and 0.9996 Telmisartan respectively. The validity of the proposed method was assessed by applying the standard addition technique where the percentage recovery of the added standard was found to be 99.63 and 100.31 for Benidipine HCl and Telmisartan. The limit of detection and quantification were calculated and found to be 0.1354μg/mL and 0.4103μg/mL and 1.6823 μg/mL and 5.0980 μg/mL for Benidipine HCl and Telmisartan respectively. The proposed method is recommended for routine analysis of Benidipine Hydrochloride and Telmisartan in bulk and pharmaceutical dosage forms in regular quality control testing laboratories.

Keywords: Benidipine Hydrochloride, Telmisartan, UV Spectrophotometry, Beer's Law, Validation.


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