European Journal of Biomedical and Pharmaceutical Sciences

A STUDY ON SYNTHESIS AND CHARACTERISATION OF SOME NOVEL QUINAZOLINONES

P. Siva Kumar*, S. Saddam Hussain and AVS Geetha Sameera

ABSTRACT

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. The heterocyclic compounds are fundamentals of life, like haeme derivatives in blood & chlorophyll essential for photosynthesis in plants. Also the DNA & RNA are containing heterocycles. The study aims to synthesize simple derivatives of quinazoline by combining with aromatic primary amine, hydrazine hydrate and benzoxazine. The synthesized compounds were characterized by melting point analysis. Melting point was recorded and compared with the standard references. The characterization of compounds provided further scope in the research towards the discovery of new derivatives for several ailments. The biological evaluation could be beneficial for future studies.

Keywords: Heterocyclic compounds, benzoxazine, quinazoline, primary amine, hydrazine hydrate and benzoxazine.