Abstract
DEVELOPMENT AND CHARACTERISATION OF FAST DISINTEGRATING TABLET OF AMLODIPINE BESYLATE USING MUCILAGE OF PLANTAGE OVATA AS SUPER DISINTEGRANT

R. Kusuma*, P. Mani Chandrika, Ann Merin Pinheriro, G. Indhu, S. Lakshmi, P. Manasa and K. Nikitha

ABSTRACT

The objective of the study was to formulate and evaluate fast dissolving tablet of Amlodipine. Direct compression method was used to formulate fast dissolving tablet of Amlodipine by employing amount of croscarmellose as super disintegrant and Plantago ovata as a natural disintegrate material along with direct compressible lactose to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration time, drug content and in-vitro dissolution studies. Based on wetting time, disintegration time, the formulation containing croscarmellose sodium and sodium starch glycolate was found to be promising and tested for in-vitro drug release pattern in 6.8 phosphate buffer, short term stability and drug- super disintegrants interaction. F4 Formulation as processed excipient was found to be the best for the preparation of Amlodipine orally disintegrating tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations. Therefore, we concluded that the Plantago ovata mucilage as a natural super disintegrant in the tablet is suitable for the formulation of fast disintegrating tablet.

Keywords: Amlodipine, natural disintegrants, FTIR studies, direct compression technique, in-vitro drug release studies, stability study.


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