Abstract
A STUDY ON EVALUATING PRESCRIBING PATTERN OF ADVERSE DRUG REACTION REPORTED WITH USE OF ANTIMICROBIAL AGENTS IN TERTIARYCARE TEACHING HOSPITAL

Dr. Zeenath Unnissa*, Juveria Salim*, Mohammed Ali*, Mohammed Saleem Ali*

ABSTRACT

Background: Antimicrobials are frequently utilized in tertiary care hospitals. Rational use of Antimicrobial agents is extremely essential for improving patient safety on long run use to avoid antimicrobial resistance in hospitalized patients. Antimicrobial agents are considered one of the class of medications and common causative cause of adverse drug reactions (ADRs). A prospective observational study was carried out for duration of 4 months with sample size of 100 patients. 11 ADRs were identified during this study. Detection of the ADR was done using Naranjo Causality assessment scale. The severity of the ADRS was assessed using the Hartwig and Siegel scale. Majority of the ADRs were seen within the patients of age group 20-59 years. The most common ADR among the patients is rashes 2(18.1%), nausea 2 (18.1%), vomiting 2 (18.1%), headache 1 (9.09%), palpitation 1(9.09%), constipation 2 (18.1%), diarrhoea 1 (9.09%) In our study majority of the ADRS were due to the use of the Betalactum (38%) Anthelminthic & Antiamoebics (26%), Quinolones (12%), Macrolides (6%) others (12%). From 11 ADRs (based on the causality assessment Naranjo scale) detection of ADR being identified as 6 (54.4%) were probable, 3 (27.2%) possible, 2 (18.1 %) definite, 0% were unlikely. The severity assessment was done using the Hartwig And Siegel scale and severity of reactions appeared to be mild in 8 (72.72%), moderate in 3 (27.27%), none of reaction were severe. The present study provide source of information in regards to ADRs reported with the utilization of AMA. This would help the healthcare practioners for safe and more rational use of it in hospitalized patients.

Keywords: Adverse drug reaction, Anti-Microbial Agents, Patient Safety, Beta Lactum, Causality assessment and severity assessment.


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